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How to use the Biophilia Tracker device to assist in the treatment of Parkinson's

Motor complications (fluctuations of symptoms and dyskinesia) are common symptoms in the middle and late stages of Parkinson's disease. Adjusting the type, dosage, and frequency of medication can improve symptoms. Surgical treatments such as deep brain stimulation (DBS) are also effective. The Emotion Matrix function in the Biophilia nls device can effectively relieve brain pressure and relieve human emotions.

What are the obvious clinical manifestations of Parkinson's
1. Static tremor is the first symptom of most PD patients. It often starts from one side of the hand, and the typical person shows a kind of "rubbing pill-like" tremor. The tremor frequency is 4~6Hz. As the disease progresses, the tremor gradually spreads to the entire limbs, and even affects the trunk, head and face. The tremor becomes more obvious when emotionally excited, stressed, and anxious. A strong will and effort can temporarily suppress the tremor, but it tends to intensify afterwards. It disappears completely during sleep or anesthesia.

2. Myotonia (myotonia) The muscle rigidity of the extrapyramidal system is different from that of the cone system. The muscle tension of the actuating and antagonist muscles is increased. At this time, the patient's own feeling is muscle stiffness, which is laborious, heavy and fatigued during activities. When the patient’s joints do passive exercise, if the increased muscle tension is always consistent and the resistance is uniform, similar to the feeling when bending a soft lead tube, it is "lead tube-like rigidity"; if the patient has increased muscle tension and tremor , You feel intermittent pauses in uniform resistance, such as gear rotation, it is "gear-like rigidity".

3. Slow movement is often the most disabling symptom of PD patients, affecting many movements in daily life. When the patient is lying in bed, it is difficult to turn over and stand up from the sitting position. The movements of tying shoelaces, buckling buttons, putting on and taking off shoes and socks, washing face, brushing teeth and shaving are slow and difficult to complete. When writing, the words become smaller and smaller, which is called overwriting. Signs: When walking, the back and forth swing of the upper limbs is reduced or disappeared, the walking is dragged, the step distance becomes smaller (broken steps), the serious person has difficulty in starting, unable to move, the feet are like sticking to the ground (frozen gait), and once When you take a step, you rush forward with smaller steps. The faster you rush, the "can't stop", you can't stop in time, and it is difficult to turn, which is called "panic gait"; facial expression muscles are affected, and it is manifested as a lack of expression. Few blinks, binocular gaze, showing a "mask face"; muscle involvement in the mouth, tongue, palate, pharynx, and vocal cords can be manifested as dysphagia, salivation, low voice, and slurred speech.

4. Posture balance disorder In the middle and late stages of the disease, most patients will have balance difficulties. These patients may still be sensitive to PD treatment drugs, but the balance disorder cannot be corrected with drugs. Once this happens, the patient should use crutches or a walking frame to avoid falling.

5. Other due to muscle rigidity of the limbs, trunk and neck muscles, the patient has head tilt, trunk flexion, upper arm adduction, elbow flexion, wrist extension, finger adduction, thumb to palm, and interphalangeal joint extension Straight, hip and knee joints are slightly curved. In the later stages of the illness, these postures aggravate, with the head lowered and the back flexed significantly. Severe muscle rigidity can cause pain in the limbs.

The newly upgraded Biophilia Tracker X4 MAX version fixes the deficiencies in the X3 version, makes the device run more smoothly, and has more complete functions, and is also more friendly.

Parkinson is caused by those main reasons
The cause is unknown

(1) Genetic factors: Early scholars have noticed that 5% to 20% of PD patient family members have at least one person suffering from PD. In 1996, an Italian autosomal dominant PD family was discovered. The disease gene is the asymuclein gene located at 4021-q23. There is a misconception mutation (G209A) at base 29 of exon 4, which results in the substitution of amino acid at position 53 of the protein product from alanine to threonine, which makes Heredity has become a hot spot in the study of the etiology of PD. Later, it was also found that symuclein is an important component in the Lewy body, a pathological marker of PD (including sporadic PD). In 198, a Japanese scholar reported the second disease-causing gene Parkin (located at 6025.2-27) of PD. Since then, DJ1, PINK-1, LRKK2 and other PD-causing genes have been confirmed in a PD family, and new PD-causing genes are still being discovered.

(2) Environmental toxicants: The exposure of pesticides, herbicides, rotenone, manganese, trichloroethylene and other environmental toxicants can increase the risk of PD.

The pathogenesis of Parkinsonism has the following theories:

(1) Mitochondrial dysfunction: Pathological evidence found that the activity of mitochondrial respiratory chain complex I was found only in the substantia nigra in the brain of PD patients. After that, it was found that mitochondrial respiratory chain complex I also existed in the muscles and platelets of PD patients. However, the degree of decline is less than that of the basal ganglia.

(2) Oxidative stress: Compared with other parts of the brain, the dense part of the substantia nigra is exposed to a higher level of oxidative stress. In the dopamine neurons remaining in PD patients, it may be compensatory to cause dopamine toxicity Accelerate, or increase the activity of MAO-B, or lack of reduced glutathione, resulting in H2O2 can not be effectively eliminated, generating highly toxic hydroxyl free radicals. Oxidative stress and mitochondrial dysfunction are mutually cause and effect, a vicious circle.

(3) Abnormal protein aggregation: After genetic mutation or environmental toxicants, the spatial conformation of alpha synuclein is abnormal, which leads to its abnormal aggregation and severe neurotoxicity. This is the main progress in the research of PD pathogenesis in the past 10 years. How? It is a hot topic of PD research to rent out its abnormal aggregation and how to prevent the spread of this neurotoxicity.

(4) Immune inflammatory mechanism: The immune activation of microglia in PD patients is also considered to be an important link in the pathogenesis of PD.

In short, the various factors in the above-mentioned pathogenesis work together in a causal and vicious circle, leading to selective destruction of substantia nigra neurons, reducing dopamine synthesis and secretion and other neurochemical changes, and causing a series of basal ganglia loops. Change, and finally show various clinical manifestations of PD.

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